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1fr2

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==CRYSTAL STRUCTURE OF THE E9 DNASE DOMAIN WITH A MUTANT IMMUNITY PROTEIN IM9(E41A)==
==CRYSTAL STRUCTURE OF THE E9 DNASE DOMAIN WITH A MUTANT IMMUNITY PROTEIN IM9(E41A)==
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<StructureSection load='1fr2' size='340' side='right' caption='[[1fr2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='1fr2' size='340' side='right'caption='[[1fr2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1fr2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FR2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1fr2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FR2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bxi|1bxi]], [[1emv|1emv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxyribonuclease_I Deoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.1 3.1.21.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fr2 OCA], [https://pdbe.org/1fr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fr2 RCSB], [https://www.ebi.ac.uk/pdbsum/1fr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fr2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fr2 OCA], [http://pdbe.org/1fr2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fr2 RCSB], [http://www.ebi.ac.uk/pdbsum/1fr2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fr2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. [[http://www.uniprot.org/uniprot/CEA9_ECOLX CEA9_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
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[https://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Colicin|Colicin]]
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*[[Colicin 3D structures|Colicin 3D structures]]
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*[[Colicin Immunity Protein|Colicin Immunity Protein]]
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*[[Colicin immunity protein 3D structures|Colicin immunity protein 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Deoxyribonuclease I]]
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[[Category: Large Structures]]
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[[Category: Hemmings, A M]]
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[[Category: Hemmings AM]]
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[[Category: James, R]]
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[[Category: James R]]
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[[Category: Kleanthous, C]]
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[[Category: Kleanthous C]]
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[[Category: Kuhlmann, U C]]
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[[Category: Kuhlmann UC]]
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[[Category: Moore, G M]]
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[[Category: Moore GM]]
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[[Category: Pommer, A J]]
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[[Category: Pommer AJ]]
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[[Category: Hnh-motif]]
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[[Category: Immune system]]
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[[Category: Protein-protein complex]]
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[[Category: Zinc containing enzyme]]
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Current revision

CRYSTAL STRUCTURE OF THE E9 DNASE DOMAIN WITH A MUTANT IMMUNITY PROTEIN IM9(E41A)

PDB ID 1fr2

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