1fxh

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{{Seed}}
 
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[[Image:1fxh.png|left|200px]]
 
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==MUTANT OF PENICILLIN ACYLASE IMPAIRED IN CATALYSIS WITH PHENYLACETIC ACID IN THE ACTIVE SITE==
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The line below this paragraph, containing "STRUCTURE_1fxh", creates the "Structure Box" on the page.
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<StructureSection load='1fxh' size='340' side='right'caption='[[1fxh]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fxh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FXH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PAC:2-PHENYLACETIC+ACID'>PAC</scene></td></tr>
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{{STRUCTURE_1fxh| PDB=1fxh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fxh OCA], [https://pdbe.org/1fxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fxh RCSB], [https://www.ebi.ac.uk/pdbsum/1fxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fxh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAC_ECOLX PAC_ECOLX]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/1fxh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fxh ConSurf].
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<div style="clear:both"></div>
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===MUTANT OF PENICILLIN ACYLASE IMPAIRED IN CATALYSIS WITH PHENYLACETIC ACID IN THE ACTIVE SITE===
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==See Also==
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*[[Penicillin acylase|Penicillin acylase]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11239085}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11239085 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11239085}}
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==About this Structure==
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1FXH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FXH OCA].
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==Reference==
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Characterization of the beta-lactam binding site of penicillin acylase of Escherichia coli by structural and site-directed mutagenesis studies., Alkema WB, Hensgens CM, Kroezinga EH, de Vries E, Floris R, van der Laan JM, Dijkstra BW, Janssen DB, Protein Eng. 2000 Dec;13(12):857-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11239085 11239085]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Penicillin amidase]]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Alkema WB]]
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[[Category: Alkema, W B.]]
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[[Category: Dijkstra BW]]
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[[Category: Dijkstra, B W.]]
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[[Category: Floris R]]
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[[Category: Floris, R.]]
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[[Category: Hensgens CM]]
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[[Category: Hensgens, C M.]]
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[[Category: Janssen DB]]
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[[Category: Janssen, D B.]]
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[[Category: Kroezinga EH]]
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[[Category: Kroezinga, E H.]]
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[[Category: De Vries E]]
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[[Category: Laan, J M.van der.]]
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[[Category: Van der Laan JM]]
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[[Category: Vries, E de.]]
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[[Category: Ntn-hydrolase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:05:27 2008''
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Current revision

MUTANT OF PENICILLIN ACYLASE IMPAIRED IN CATALYSIS WITH PHENYLACETIC ACID IN THE ACTIVE SITE

PDB ID 1fxh

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