1g2a

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{{Seed}}
 
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[[Image:1g2a.png|left|200px]]
 
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==THE CRYSTAL STRUCTURE OF E.COLI PEPTIDE DEFORMYLASE COMPLEXED WITH ACTINONIN==
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The line below this paragraph, containing "STRUCTURE_1g2a", creates the "Structure Box" on the page.
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<StructureSection load='1g2a' size='340' side='right'caption='[[1g2a]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g2a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G2A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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{{STRUCTURE_1g2a| PDB=1g2a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g2a OCA], [https://pdbe.org/1g2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g2a RCSB], [https://www.ebi.ac.uk/pdbsum/1g2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g2a ProSAT]</span></td></tr>
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</table>
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===THE CRYSTAL STRUCTURE OF E.COLI PEPTIDE DEFORMYLASE COMPLEXED WITH ACTINONIN===
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== Function ==
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[https://www.uniprot.org/uniprot/DEF_ECOLI DEF_ECOLI] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11158755 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/1g2a_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11158755}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1G2A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2A OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g2a ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor., Clements JM, Beckett RP, Brown A, Catlin G, Lobell M, Palan S, Thomas W, Whittaker M, Wood S, Salama S, Baker PJ, Rodgers HF, Barynin V, Rice DW, Hunter MG, Antimicrob Agents Chemother. 2001 Feb;45(2):563-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11158755 11158755]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Formylmethionine deformylase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Baker PJ]]
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[[Category: Baker, P J.]]
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[[Category: Barynin V]]
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[[Category: Barynin, V.]]
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[[Category: Beckett P]]
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[[Category: Beckett, P.]]
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[[Category: Brown A]]
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[[Category: Brown, A.]]
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[[Category: Catlin C]]
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[[Category: Catlin, C.]]
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[[Category: Clements JM]]
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[[Category: Clements, J M.]]
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[[Category: Hunter MG]]
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[[Category: Hunter, M G.]]
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[[Category: Lobell M]]
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[[Category: Lobell, M.]]
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[[Category: Palan S]]
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[[Category: Palan, S.]]
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[[Category: Rice DW]]
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[[Category: Rice, D W.]]
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[[Category: Rodgers HF]]
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[[Category: Rodgers, H F.]]
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[[Category: Thomas W]]
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[[Category: Thomas, W.]]
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[[Category: Whittaker M]]
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[[Category: Whittaker, M.]]
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[[Category: Actinonin]]
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[[Category: Inhibition]]
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[[Category: Polypeptide deformylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:18:03 2008''
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Current revision

THE CRYSTAL STRUCTURE OF E.COLI PEPTIDE DEFORMYLASE COMPLEXED WITH ACTINONIN

PDB ID 1g2a

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