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1g4b

From Proteopedia

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[[Image:1g4b.png|left|200px]]
 
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{{STRUCTURE_1g4b| PDB=1g4b | SCENE= }}
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==CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM==
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<StructureSection load='1g4b' size='340' side='right'caption='[[1g4b]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1g4b]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G4B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g4b OCA], [https://pdbe.org/1g4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g4b RCSB], [https://www.ebi.ac.uk/pdbsum/1g4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g4b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSLU_ECOLI HSLU_ECOLI] ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.<ref>PMID:8662828</ref> <ref>PMID:8650174</ref> <ref>PMID:9288941</ref> <ref>PMID:9393683</ref> <ref>PMID:10452560</ref> <ref>PMID:10419524</ref> <ref>PMID:15696175</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/1g4b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g4b ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM===
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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{{ABSTRACT_PUBMED_11250202}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1g4b]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G4B OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:011250202</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Chung, C H.]]
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[[Category: Large Structures]]
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[[Category: Eom, S H.]]
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[[Category: Chung CH]]
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[[Category: Franklin, M C.]]
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[[Category: Eom SH]]
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[[Category: Im, Y J.]]
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[[Category: Franklin MC]]
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[[Category: Kamtekar, S.]]
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[[Category: Im YJ]]
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[[Category: Lee, C S.]]
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[[Category: Kamtekar S]]
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[[Category: Rho, S H.]]
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[[Category: Lee CS]]
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[[Category: Seong, I S.]]
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[[Category: Rho SH]]
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[[Category: Song, J J.]]
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[[Category: Seong IS]]
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[[Category: Wang, J.]]
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[[Category: Song JJ]]
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[[Category: Chaperone-hydrolase complex]]
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[[Category: Wang J]]
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[[Category: Hslvu]]
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[[Category: Peptidase-atpase complex]]
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Current revision

CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM

PDB ID 1g4b

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