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1g61

From Proteopedia

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[[Image:1g61.gif|left|200px]]<br /><applet load="1g61" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1g61, resolution 1.3&Aring;" />
 
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'''CRYSTAL STRUCTURE OF M.JANNASCHII EIF6'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF M.JANNASCHII EIF6==
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Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.
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<StructureSection load='1g61' size='340' side='right'caption='[[1g61]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1g61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G61 FirstGlance]. <br>
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1G61 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G61 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g61 OCA], [https://pdbe.org/1g61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g61 RCSB], [https://www.ebi.ac.uk/pdbsum/1g61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g61 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1g61 TOPSAN]</span></td></tr>
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==Reference==
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</table>
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Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11101899 11101899]
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== Function ==
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[https://www.uniprot.org/uniprot/IF6_METJA IF6_METJA] Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex (By similarity).<ref>PMID:11101899</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/1g61_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g61 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Beckmann R]]
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[[Category: Beckmann, R.]]
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[[Category: Burley SK]]
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[[Category: Burley, S K.]]
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[[Category: Groft CM]]
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[[Category: Groft, C M.]]
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[[Category: Sali A]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Sali, A.]]
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[[Category: alpha-beta-barrel velcro closure subdomain]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:46:30 2008''
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Current revision

CRYSTAL STRUCTURE OF M.JANNASCHII EIF6

PDB ID 1g61

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