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1g8x

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[[Image:1g8x.png|left|200px]]
 
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{{STRUCTURE_1g8x| PDB=1g8x | SCENE= }}
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==STRUCTURE OF A GENETICALLY ENGINEERED MOLECULAR MOTOR==
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<StructureSection load='1g8x' size='340' side='right'caption='[[1g8x]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===STRUCTURE OF A GENETICALLY ENGINEERED MOLECULAR MOTOR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1g8x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G8X FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11226153}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g8x OCA], [https://pdbe.org/1g8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g8x RCSB], [https://www.ebi.ac.uk/pdbsum/1g8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g8x ProSAT]</span></td></tr>
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[[1g8x]] is a 2 chain structure of [[Actinin]] and [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G8X OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYS2_DICDI MYS2_DICDI] Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.[https://www.uniprot.org/uniprot/ACTNA_DICDI ACTNA_DICDI] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Increases the actin-stimulated ATPase activity of myosin. Involved in vegetative cell growth, phagocytosis, motility and development, probably through stabilization of the actin network in the cortical cytoskeleton.<ref>PMID:10411959</ref> <ref>PMID:10413681</ref> <ref>PMID:10704840</ref> <ref>PMID:1732064</ref> <ref>PMID:3956480</ref> <ref>PMID:6746725</ref> <ref>PMID:8486739</ref> <ref>PMID:8937986</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/1g8x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g8x ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Actinin|Actinin]]
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*[[Actinin 3D structures|Actinin 3D structures]]
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*[[Myosin|Myosin]]
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011226153</ref><ref group="xtra">PMID:011470434</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
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[[Category: Fujita-Becker, S.]]
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[[Category: Large Structures]]
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[[Category: Kliche, W.]]
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[[Category: Fujita-Becker S]]
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[[Category: Kollmar, M.]]
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[[Category: Kliche W]]
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[[Category: Kull, F J.]]
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[[Category: Kollmar M]]
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[[Category: Manstein, D J.]]
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[[Category: Kull FJ]]
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[[Category: Alpha-actinin]]
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[[Category: Manstein DJ]]
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[[Category: Dictyostelium]]
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[[Category: Lever arm]]
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[[Category: Motor]]
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[[Category: Myosin]]
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[[Category: Protein engineering]]
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[[Category: Structural protein]]
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Current revision

STRUCTURE OF A GENETICALLY ENGINEERED MOLECULAR MOTOR

PDB ID 1g8x

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