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1gid

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(New page: 200px<br /><applet load="1gid" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gid, resolution 2.500&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:1gid.jpg|left|200px]]<br /><applet load="1gid" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1gid, resolution 2.500&Aring;" />
 
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'''CRYSTAL STRUCTURE OF A GROUP I RIBOZYME DOMAIN: PRINCIPLES OF RNA PACKING'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF A GROUP I RIBOZYME DOMAIN: PRINCIPLES OF RNA PACKING==
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Group I self-splicing introns catalyze their own excision from precursor, RNAs by way of a two-step transesterification reaction. The catalytic core, of these ribozymes is formed by two structural domains. The 2.8-angstrom, crystal structure of one of these, the P4-P6 domain of the Tetrahymena, thermophila intron, is described. In the 160-nucleotide domain, a sharp, bend allows stacked helices of the conserved core to pack alongside, helices of an adjacent region. Two specific long-range interactions clamp, the two halves of the domain together: a two-Mg2+-coordinated, adenosine-rich corkscrew plugs into the minor groove of a helix, and a, GAAA hairpin loop binds to a conserved 11-nucleotide internal loop. Metal-, and ribose-mediated backbone contacts further stabilize the close, side-by-side helical packing. The structure indicates the extent of RNA, packing required for the function of large ribozymes, the spliceosome, and, the ribosome.
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<StructureSection load='1gid' size='340' side='right'caption='[[1gid]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GID FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gid OCA], [https://pdbe.org/1gid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gid RCSB], [https://www.ebi.ac.uk/pdbsum/1gid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gid ProSAT]</span></td></tr>
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</table>
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==About this Structure==
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==See Also==
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1GID is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG and NCO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GID OCA].
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of a group I ribozyme domain: principles of RNA packing., Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA, Science. 1996 Sep 20;273(5282):1678-85. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8781224 8781224]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Synthetic construct]]
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[[Category: Cate, J.H.]]
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[[Category: Cate JH]]
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[[Category: Cech, T.R.]]
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[[Category: Cech TR]]
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[[Category: Doudna, J.A.]]
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[[Category: Doudna JA]]
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[[Category: Golden, B.L.]]
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[[Category: Golden BL]]
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[[Category: Gooding, A.R.]]
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[[Category: Gooding AR]]
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[[Category: Kundrot, C.E.]]
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[[Category: Kundrot CE]]
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[[Category: Podell, E.]]
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[[Category: Podell E]]
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[[Category: Zhou, K.]]
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[[Category: Zhou K]]
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[[Category: MG]]
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[[Category: NCO]]
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[[Category: p4-p6 ribozyme domain of the tetrahymena group i intron]]
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[[Category: rna]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:22:26 2007''
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Current revision

CRYSTAL STRUCTURE OF A GROUP I RIBOZYME DOMAIN: PRINCIPLES OF RNA PACKING

PDB ID 1gid

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