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1gri

From Proteopedia

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{{Seed}}
 
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[[Image:1gri.png|left|200px]]
 
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<!--
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==GRB2==
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The line below this paragraph, containing "STRUCTURE_1gri", creates the "Structure Box" on the page.
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<StructureSection load='1gri' size='340' side='right'caption='[[1gri]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gri]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GRI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gri OCA], [https://pdbe.org/1gri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gri RCSB], [https://www.ebi.ac.uk/pdbsum/1gri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gri ProSAT]</span></td></tr>
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{{STRUCTURE_1gri| PDB=1gri | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/1gri_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gri ConSurf].
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<div style="clear:both"></div>
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===GRB2===
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==See Also==
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*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_7716522}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 7716522 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_7716522}}
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==About this Structure==
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1GRI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GRI OCA].
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==Reference==
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Crystal structure of the mammalian Grb2 adaptor., Maignan S, Guilloteau JP, Fromage N, Arnoux B, Becquart J, Ducruix A, Science. 1995 Apr 14;268(5208):291-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7716522 7716522]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arnoux, B.]]
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[[Category: Arnoux B]]
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[[Category: Ducruix, A.]]
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[[Category: Ducruix A]]
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[[Category: Maignan, S.]]
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[[Category: Maignan S]]
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[[Category: Sh2]]
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[[Category: Sh3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:57:23 2008''
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Current revision

GRB2

PDB ID 1gri

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