1hjo

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[[Image:1hjo.png|left|200px]]
 
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==ATPase domain of human heat shock 70kDa protein 1==
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The line below this paragraph, containing "STRUCTURE_1hjo", creates the "Structure Box" on the page.
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<StructureSection load='1hjo' size='340' side='right'caption='[[1hjo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hjo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HJO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_1hjo| PDB=1hjo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hjo OCA], [https://pdbe.org/1hjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hjo RCSB], [https://www.ebi.ac.uk/pdbsum/1hjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hjo ProSAT]</span></td></tr>
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</table>
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===HEAT-SHOCK 70KD PROTEIN 42KD ATPASE N-TERMINAL DOMAIN===
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== Function ==
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[https://www.uniprot.org/uniprot/HS71A_HUMAN HS71A_HUMAN] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).<ref>PMID:16537599</ref> <ref>PMID:22528486</ref> <ref>PMID:23973223</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_10216320}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 10216320 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/1hjo_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_10216320}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1hjo]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJO OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hjo ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Heat Shock Proteins]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:10216320</ref><references group="xtra"/>
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__TOC__
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[[Category: Adenosinetriphosphatase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Freeman, B C.]]
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[[Category: Large Structures]]
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[[Category: Joachimiak, A.]]
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[[Category: Freeman BC]]
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[[Category: Morimoto, R I.]]
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[[Category: Joachimiak A]]
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[[Category: Osipiuk, J.]]
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[[Category: Morimoto RI]]
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[[Category: Walsh, M A.]]
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[[Category: Osipiuk J]]
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[[Category: Atp-binding]]
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[[Category: Walsh MA]]
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[[Category: Chaperone]]
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[[Category: Heat shock]]
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[[Category: Hydrolase]]
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Current revision

ATPase domain of human heat shock 70kDa protein 1

PDB ID 1hjo

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OCA

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