1hmh

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[[Image:1hmh.jpg|left|200px]]<br /><applet load="1hmh" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hmh, resolution 2.600&Aring;" />
 
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'''THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME'''<br />
 
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==Overview==
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==THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME==
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The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired stems and a core of highly conserved, non-complementary nucleotides essential for catalysis. The X-ray crystallographic structure of a hammerhead RNA-DNA ribozyme-inhibitor complex at 2.6 A resolution reveals that the base-paired stems are A-form helices and that the core has two structural domains. The first domain is formed by the sequence 5'-CUGA following stem I and is a sharp turn identical to the uridine turn of transfer RNA, whereas the second is a non-Watson-Crick three-base-pair duplex with a divalent-ion binding site. The phosphodiester backbone of the DNA inhibitor strand is splayed out at the phosphate 5' to the cleavage site. The structure indicates that the ribozyme may destabilize a substrate strand in order to facilitate twisting of the substrate to allow cleavage of the scissile bond.
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<StructureSection load='1hmh' size='340' side='right'caption='[[1hmh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hmh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HMH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hmh OCA], [https://pdbe.org/1hmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hmh RCSB], [https://www.ebi.ac.uk/pdbsum/1hmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hmh ProSAT]</span></td></tr>
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</table>
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==About this Structure==
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==See Also==
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1HMH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMH OCA].
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Three-dimensional structure of a hammerhead ribozyme., Pley HW, Flaherty KM, McKay DB, Nature. 1994 Nov 3;372(6501):68-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7969422 7969422]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Flaherty KM]]
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[[Category: Flaherty, K M.]]
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[[Category: McKay DB]]
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[[Category: McKay, D B.]]
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[[Category: Pley HW]]
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[[Category: Pley, H W.]]
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[[Category: dna-rna hammerhead ribozyme]]
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[[Category: loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:02:47 2008''
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THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME

PDB ID 1hmh

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