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1hoo

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[[Image:1hoo.png|left|200px]]
 
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{{STRUCTURE_1hoo| PDB=1hoo | SCENE= }}
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==STRUCTURE OF GUANINE NUCLEOTIDE (GPPCP) COMPLEX OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI AT PH 6.5 AND 25 DEGREES CELSIUS==
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<StructureSection load='1hoo' size='340' side='right'caption='[[1hoo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===STRUCTURE OF GUANINE NUCLEOTIDE (GPPCP) COMPLEX OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI AT PH 6.5 AND 25 DEGREES CELSIUS===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hoo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HOO FirstGlance]. <br>
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{{ABSTRACT_PUBMED_8663109}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNH:AMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNH</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hoo OCA], [https://pdbe.org/1hoo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hoo RCSB], [https://www.ebi.ac.uk/pdbsum/1hoo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hoo ProSAT]</span></td></tr>
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[[1hoo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HOO OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PURA_ECOLI PURA_ECOLI] Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).[HAMAP-Rule:MF_00011]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ho/1hoo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hoo ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Adenylosuccinate Synthetase|Adenylosuccinate Synthetase]]
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*[[Adenylosuccinate synthetase 3D structures|Adenylosuccinate synthetase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:008663109</ref><references group="xtra"/>
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[[Category: Adenylosuccinate synthase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bruns, C.]]
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[[Category: Large Structures]]
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[[Category: Fromm, H J.]]
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[[Category: Bruns C]]
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[[Category: Honzatko, R B.]]
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[[Category: Fromm HJ]]
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[[Category: Hou, Z.]]
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[[Category: Honzatko RB]]
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[[Category: Poland, B W.]]
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[[Category: Hou Z]]
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[[Category: Gtp-hydrolysing enzyme]]
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[[Category: Poland BW]]
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[[Category: Ligase]]
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[[Category: Purine nucleotide biosynthesis]]
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Current revision

STRUCTURE OF GUANINE NUCLEOTIDE (GPPCP) COMPLEX OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI AT PH 6.5 AND 25 DEGREES CELSIUS

PDB ID 1hoo

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