1hqy

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{{Seed}}
 
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[[Image:1hqy.png|left|200px]]
 
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==Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU==
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The line below this paragraph, containing "STRUCTURE_1hqy", creates the "Structure Box" on the page.
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<StructureSection load='1hqy' size='340' side='right'caption='[[1hqy]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hqy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HQY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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{{STRUCTURE_1hqy| PDB=1hqy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqy OCA], [https://pdbe.org/1hqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hqy RCSB], [https://www.ebi.ac.uk/pdbsum/1hqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hqy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSLV_ECOLI HSLV_ECOLI] Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. The complex has been shown to be involved in the specific degradation of heat shock induced transcription factors such as RpoH and SulA. In addition, small hydrophobic peptides are also hydrolyzed by HslV. HslV has weak protease activity even in the absence of HslU, but this activity is induced more than 100-fold in the presence of HslU. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins.<ref>PMID:8662828</ref> <ref>PMID:8650174</ref> <ref>PMID:9288941</ref> <ref>PMID:9393683</ref> <ref>PMID:10452560</ref> <ref>PMID:10419524</ref> <ref>PMID:15696175</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/1hqy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hqy ConSurf].
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<div style="clear:both"></div>
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===Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU===
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11709174 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_11709174}}
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[[Category: Chung CH]]
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[[Category: Eom SH]]
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==About this Structure==
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[[Category: Franklin MC]]
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1HQY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQY OCA].
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[[Category: Kamtekar S]]
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[[Category: Seong IS]]
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==Reference==
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[[Category: Song JJ]]
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Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU., Wang J, Song JJ, Seong IS, Franklin MC, Kamtekar S, Eom SH, Chung CH, Structure. 2001 Nov;9(11):1107-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11709174 11709174]
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[[Category: Wang J]]
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[[Category: Escherichia coli]]
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[[Category: Protein complex]]
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[[Category: Chung, C H.]]
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[[Category: Eom, S H.]]
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[[Category: Franklin, M C.]]
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[[Category: Kamtekar, S.]]
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[[Category: Seong, I S.]]
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[[Category: Song, J J.]]
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[[Category: Wang, J.]]
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[[Category: Hslvu]]
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[[Category: Peptidase-atpase complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:33:51 2008''
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Current revision

Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU

PDB ID 1hqy

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