This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1huu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1huu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1huu, resolution 2.0&Aring;" /> '''DNA-BINDING PROTEIN H...)
Current revision (07:30, 7 February 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1huu.jpg|left|200px]]<br /><applet load="1huu" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1huu, resolution 2.0&Aring;" />
 
-
'''DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS'''<br />
 
-
==Overview==
+
==DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS==
-
The prokaryotic protein HU, integration host factor (IHF) from Escherichia, coli, and transcription factor 1 (TF1) from bacteriophage SPO1 are closely, related molecules. Biochemical results suggest that the role of these, proteins is to bind and bend DNA. From the high-resolution structure of, HU, we propose a model for this interaction with DNA. Crucial amino acid, differences between the proteins can be rationalized in terms of their, different specific functions.
+
<StructureSection load='1huu' size='340' side='right'caption='[[1huu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1huu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HUU FirstGlance]. <br>
-
1HUU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HUU OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1huu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1huu OCA], [https://pdbe.org/1huu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1huu RCSB], [https://www.ebi.ac.uk/pdbsum/1huu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1huu ProSAT]</span></td></tr>
-
==Reference==
+
</table>
-
A protein structural motif that bends DNA., White SW, Appelt K, Wilson KS, Tanaka I, Proteins. 1989;5(4):281-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2508086 2508086]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/DBH_GEOSE DBH_GEOSE] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/1huu_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1huu ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Appelt, K.]]
+
[[Category: Appelt K]]
-
[[Category: Tanaka, I.]]
+
[[Category: Tanaka I]]
-
[[Category: White, S.W.]]
+
[[Category: White SW]]
-
[[Category: Wilson, K.S.]]
+
[[Category: Wilson KS]]
-
[[Category: alpha/beta class]]
+
-
[[Category: dna supercoiling]]
+
-
[[Category: dna-binding protein]]
+
-
[[Category: minor groove binder]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:50:21 2007''
+

Current revision

DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS

PDB ID 1huu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools