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1i1i

From Proteopedia

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{{Seed}}
 
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[[Image:1i1i.png|left|200px]]
 
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<!--
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==NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1i1i", creates the "Structure Box" on the page.
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<StructureSection load='1i1i' size='340' side='right'caption='[[1i1i]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1i1i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I1I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1i1i| PDB=1i1i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1i OCA], [https://pdbe.org/1i1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i1i RCSB], [https://www.ebi.ac.uk/pdbsum/1i1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i1i ProSAT]</span></td></tr>
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</table>
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===NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE===
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== Function ==
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[https://www.uniprot.org/uniprot/NEUL_RAT NEUL_RAT] Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11248043}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11248043 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/1i1i_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11248043}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1I1I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1I OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i1i ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structure of neurolysin reveals a deep channel that limits substrate access., Brown CK, Madauss K, Lian W, Beck MR, Tolbert WD, Rodgers DW, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3127-32. Epub 2001 Mar 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11248043 11248043]
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</StructureSection>
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[[Category: Neurolysin]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Beck MR]]
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[[Category: Beck, M R.]]
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[[Category: Brown CK]]
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[[Category: Brown, C K.]]
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[[Category: Lian W]]
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[[Category: Lian, W.]]
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[[Category: Madauss K]]
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[[Category: Madauss, K.]]
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[[Category: Rodgers DW]]
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[[Category: Rodgers, D W.]]
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[[Category: Tolbert WD]]
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[[Category: Tolbert, W D.]]
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[[Category: Endopeptidase]]
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[[Category: Neuropeptidase]]
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[[Category: Zinc metallopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:16:28 2008''
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Current revision

NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE

PDB ID 1i1i

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