1ig7

<table><tr><td colspan='2'>[[1ig7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IG7 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ig7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ig7 OCA], [http://pdbe.org/1ig7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ig7 RCSB], [http://www.ebi.ac.uk/pdbsum/1ig7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ig7 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/MSX1_MOUSE MSX1_MOUSE]] Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis.<ref>PMID:1677742</ref> <ref>PMID:7823952</ref>

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== Publication Abstract from PubMed ==

The Msx-1 homeodomain protein plays a crucial role in craniofacial, limb, and nervous system development. Homeodomain DNA-binding domains are comprised of 60 amino acids that show a high degree of evolutionary conservation. We have determined the structure of the Msx-1 homeodomain complexed to DNA at 2.2 A resolution. The structure has an unusually well-ordered N-terminal arm with a unique trajectory across the minor groove of the DNA. DNA specificity conferred by bases flanking the core TAAT sequence is explained by well ordered water-mediated interactions at Q50. Most interactions seen at the TAAT sequence are typical of the interactions seen in other homeodomain structures. Comparison of the Msx-1-HD structure to all other high resolution HD-DNA complex structures indicate a remarkably well-conserved sphere of hydration between the DNA and protein in these complexes.

Crystal structure of the Msx-1 homeodomain/DNA complex.,Hovde S, Abate-Shen C, Geiger JH Biochemistry. 2001 Oct 9;40(40):12013-21. PMID:11580277<ref>PMID:11580277</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1ig7" style="background-color:#fffaf0;"></div>

[[Category: Lk3 transgenic mice]]

[[Category: Abate-Shen, C]]

[[Category: Geiger, J H]]

[[Category: Hovde, S]]

[[Category: Transcription-dna complex]]