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1ig7

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(New page: 200px<br /><applet load="1ig7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ig7, resolution 2.20&Aring;" /> '''Msx-1 Homeodomain/DN...)
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[[Image:1ig7.gif|left|200px]]<br /><applet load="1ig7" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ig7, resolution 2.20&Aring;" />
 
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'''Msx-1 Homeodomain/DNA Complex Structure'''<br />
 
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==Overview==
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==Msx-1 Homeodomain/DNA Complex Structure==
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The Msx-1 homeodomain protein plays a crucial role in craniofacial, limb, and nervous system development. Homeodomain DNA-binding domains are, comprised of 60 amino acids that show a high degree of evolutionary, conservation. We have determined the structure of the Msx-1 homeodomain, complexed to DNA at 2.2 A resolution. The structure has an unusually, well-ordered N-terminal arm with a unique trajectory across the minor, groove of the DNA. DNA specificity conferred by bases flanking the core, TAAT sequence is explained by well ordered water-mediated interactions at, Q50. Most interactions seen at the TAAT sequence are typical of the, interactions seen in other homeodomain structures. Comparison of the, Msx-1-HD structure to all other high resolution HD-DNA complex structures, indicate a remarkably well-conserved sphere of hydration between the DNA, and protein in these complexes.
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<StructureSection load='1ig7' size='340' side='right'caption='[[1ig7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ig7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IG7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ig7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ig7 OCA], [https://pdbe.org/1ig7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ig7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ig7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ig7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MSX1_MOUSE MSX1_MOUSE] Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis.<ref>PMID:1677742</ref> <ref>PMID:7823952</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/1ig7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ig7 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1IG7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IG7 OCA].
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*[[Hox protein|Hox protein]]
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== References ==
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==Reference==
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<references/>
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Crystal structure of the Msx-1 homeodomain/DNA complex., Hovde S, Abate-Shen C, Geiger JH, Biochemistry. 2001 Oct 9;40(40):12013-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11580277 11580277]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Abate-Shen C]]
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[[Category: Abate-Shen, C.]]
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[[Category: Geiger JH]]
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[[Category: Geiger, J.H.]]
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[[Category: Hovde S]]
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[[Category: Hovde, S.]]
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[[Category: helix-turn-helix]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:22:50 2007''
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Current revision

Msx-1 Homeodomain/DNA Complex Structure

PDB ID 1ig7

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