1imr

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[[Image:1imr.gif|left|200px]]
 
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==MOLECULAR STRUCTURE OF THE HALOGENATED ANTI-CANCER DRUG IODODOXORUBICIN COMPLEXED WITH D(TGTACA) AND D(CGATCG)==
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The line below this paragraph, containing "STRUCTURE_1imr", creates the "Structure Box" on the page.
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<StructureSection load='1imr' size='340' side='right'caption='[[1imr]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1imr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IMR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DM7:4-DEOXY-4-IODODOXORUBICIN'>DM7</scene></td></tr>
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{{STRUCTURE_1imr| PDB=1imr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1imr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imr OCA], [https://pdbe.org/1imr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1imr RCSB], [https://www.ebi.ac.uk/pdbsum/1imr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1imr ProSAT]</span></td></tr>
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</table>
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'''MOLECULAR STRUCTURE OF THE HALOGENATED ANTI-CANCER DRUG IODODOXORUBICIN COMPLEXED WITH D(TGTACA) AND D(CGATCG)'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Berger I]]
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4'-Deoxy-4'-iododoxorubicin, a halogenated anthracycline derivative, is an anticancer agent currently under Phase II clinical trials. In preclinical studies, it has demonstrated significantly reduced levels of cardiotoxicity compared to currently employed anthracyclines. It also has modified pharmacological properties resulting in an altered spectrum of experimental antitumor activity. The iodine atom at the 4' position of the sugar ring reduces the basicity and enhances the lipophilicity of this compound as compared to related anthracycline drugs. We report here single crystal X-ray diffraction studies of the complexes of 4'-deoxy-4'-iododoxorubicin with the hexanucleotide duplex sequences d(TGTACA) and d(CGATCG) at 1.6 and 1.5 A, respectively. The iodine substituent does not alter the geometry of intercalation as compared to previously solved anthracycline complexes, but appears to markedly affect the solvent environment of the structures. This could have consequences for the interaction of this drug with DNA and DNA binding proteins in cells.
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[[Category: Burke TG]]
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[[Category: Kang C]]
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==About this Structure==
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[[Category: Rich A]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMR OCA].
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[[Category: Spitzner JR]]
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[[Category: Su L]]
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==Reference==
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Molecular structure of the halogenated anti-cancer drug iododoxorubicin complexed with d(TGTACA) and d(CGATCG)., Berger I, Su L, Spitzner JR, Kang C, Burke TG, Rich A, Nucleic Acids Res. 1995 Nov 11;23(21):4488-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7501474 7501474]
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[[Category: Berger, I.]]
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[[Category: Burke, T G.]]
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[[Category: Kang, C.]]
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[[Category: Rich, A.]]
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[[Category: Spitzner, J R.]]
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[[Category: Su, L.]]
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[[Category: Complexed with drug]]
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[[Category: Double helix]]
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[[Category: Right handed dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:09:59 2008''
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Current revision

MOLECULAR STRUCTURE OF THE HALOGENATED ANTI-CANCER DRUG IODODOXORUBICIN COMPLEXED WITH D(TGTACA) AND D(CGATCG)

PDB ID 1imr

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