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1j77

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[[Image:1j77.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of Gram-negative Bacterial Heme Oxygenase Complexed with Heme==
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|PDB= 1j77 |SIZE=350|CAPTION= <scene name='initialview01'>1j77</scene>, resolution 1.50&Aring;
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<StructureSection load='1j77' size='340' side='right'caption='[[1j77]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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<table><tr><td colspan='2'>[[1j77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J77 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Heme_oxygenase Heme oxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.3 1.14.99.3] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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|GENE= hemO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 Neisseria meningitidis])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j77 OCA], [https://pdbe.org/1j77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j77 RCSB], [https://www.ebi.ac.uk/pdbsum/1j77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j77 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1qq8|1QQ8]], [[1dve|1DVE]], [[1dvg|1DVG]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j77 OCA], [http://www.ebi.ac.uk/pdbsum/1j77 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j77 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q9RGD9_NEIME Q9RGD9_NEIME]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/1j77_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j77 ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of Gram-negative Bacterial Heme Oxygenase Complexed with Heme'''
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==See Also==
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*[[Heme oxygenase 3D structures|Heme oxygenase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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We report the crystal structure of heme oxygenase from the pathogenic bacterium Neisseria meningitidis at 1.5 A and compare and contrast it with known structures of heme oxygenase-1 from mammalian sources. Both the bacterial and mammalian enzymes share the same overall fold, with a histidine contributing a ligand to the proximal side of the heme iron and a kinked alpha-helix defining the distal pocket. The distal helix differs noticeably in both sequence and conformation, and the distal pocket of the Neisseria enzyme is substantially smaller than in the mammalian enzyme. Key glycine residues provide the flexibility for the helical kink, allow close contact of the helix backbone with the heme, and may interact directly with heme ligands.
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[[Category: Large Structures]]
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==About this Structure==
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1J77 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J77 OCA].
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==Reference==
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Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1., Schuller DJ, Zhu W, Stojiljkovic I, Wilks A, Poulos TL, Biochemistry. 2001 Sep 25;40(38):11552-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11560504 11560504]
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[[Category: Heme oxygenase]]
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[[Category: Neisseria meningitidis]]
[[Category: Neisseria meningitidis]]
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[[Category: Single protein]]
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[[Category: Poulos TL]]
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[[Category: Poulos, T L.]]
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[[Category: Schuller DJ]]
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[[Category: Schuller, D J.]]
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[[Category: Stojiljkovic I]]
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[[Category: Stojiljkovic, I.]]
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[[Category: Wilks A]]
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[[Category: Wilks, A.]]
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[[Category: Zhu W]]
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[[Category: Zhu, W.]]
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[[Category: distal helix]]
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[[Category: proximal histidine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:29:34 2008''
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Current revision

Crystal Structure of Gram-negative Bacterial Heme Oxygenase Complexed with Heme

PDB ID 1j77

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