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1jh5

From Proteopedia

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{{Seed}}
 
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[[Image:1jh5.png|left|200px]]
 
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<!--
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==Crystal Structure of sTALL-1 of TNF family ligand==
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The line below this paragraph, containing "STRUCTURE_1jh5", creates the "Structure Box" on the page.
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<StructureSection load='1jh5' size='340' side='right'caption='[[1jh5]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jh5]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JH5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jh5 OCA], [https://pdbe.org/1jh5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jh5 RCSB], [https://www.ebi.ac.uk/pdbsum/1jh5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jh5 ProSAT]</span></td></tr>
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{{STRUCTURE_1jh5| PDB=1jh5 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/1jh5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jh5 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of sTALL-1 of TNF family ligand===
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==See Also==
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*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11853672}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11853672 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11853672}}
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==About this Structure==
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1JH5 is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JH5 OCA].
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==Reference==
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<ref group="xtra">PMID:11853672</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Liu, Y.]]
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[[Category: Large Structures]]
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[[Category: Opalka, N.]]
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[[Category: Liu Y]]
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[[Category: Shu, H B.]]
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[[Category: Opalka N]]
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[[Category: Xu, L.]]
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[[Category: Shu H-B]]
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[[Category: Zhang, G.]]
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[[Category: Xu L]]
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[[Category: Baff]]
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[[Category: Zhang G]]
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[[Category: Bly]]
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[[Category: Tall-1]]
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[[Category: Thank]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:19:36 2009''
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Current revision

Crystal Structure of sTALL-1 of TNF family ligand

PDB ID 1jh5

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OCA

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