1jig

<table><tr><td colspan='2'>[[1jig]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JIG FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dlp-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jig OCA], [http://pdbe.org/1jig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jig RCSB], [http://www.ebi.ac.uk/pdbsum/1jig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jig ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/DPS1_BACAN DPS1_BACAN]] Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton Fe(2+) ion (By similarity). It is capable of binding and sequestering Fe(2+) ion. Does not bind DNA.

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== Publication Abstract from PubMed ==

Bacillus anthracis is currently under intense investigation due to its primary importance as a human pathogen. Particularly important is the development of novel anti-anthrax vaccines, devoid of the current side effects. A novel class of immunogenic bacterial proteins consists of dodecamers homologous to the DNA-binding protein of Escherichia coli (Dps). Two Dps homologous genes are present in the B. anthracis genome. The crystal structures of these two proteins (Dlp-1 and Dlp-2) have been determined and are presented here. They are sphere-like proteins with an internal cavity. We also show that they act as ferritins and are thus involved in iron uptake and regulation, a fundamental function during bacterial growth.

Structure of two iron-binding proteins from Bacillus anthracis.,Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G J Biol Chem. 2002 Apr 26;277(17):15093-8. Epub 2002 Feb 8. PMID:11836250<ref>PMID:11836250</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1jig" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Battistutta, R]]

[[Category: Dundon, W G]]

[[Category: Montecucco, C]]

[[Category: Papinutto, E]]

[[Category: Pitulis, N]]

[[Category: Zanotti, G]]

[[Category: Metal transport]]