This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jmt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1jmt" [edit=sysop:move=sysop])
Current revision (07:40, 7 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1jmt.png|left|200px]]
 
-
{{STRUCTURE_1jmt| PDB=1jmt | SCENE= }}
+
==X-ray Structure of a Core U2AF65/U2AF35 Heterodimer==
-
 
+
<StructureSection load='1jmt' size='340' side='right'caption='[[1jmt]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
===X-ray Structure of a Core U2AF65/U2AF35 Heterodimer===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1jmt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JMT FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_11551507}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jmt OCA], [https://pdbe.org/1jmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jmt RCSB], [https://www.ebi.ac.uk/pdbsum/1jmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jmt ProSAT]</span></td></tr>
-
[[1jmt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMT OCA].
+
</table>
-
 
+
== Function ==
-
==Reference==
+
[https://www.uniprot.org/uniprot/U2AF1_HUMAN U2AF1_HUMAN] Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.<ref>PMID:8647433</ref>
-
<ref group="xtra">PMID:011551507</ref><references group="xtra"/>
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/1jmt_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jmt ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Burley, S K.]]
+
[[Category: Large Structures]]
-
[[Category: Green, M R.]]
+
[[Category: Burley SK]]
-
[[Category: Kielkopf, C L.]]
+
[[Category: Green MR]]
-
[[Category: Rodionova, N A.]]
+
[[Category: Kielkopf CL]]
-
[[Category: Peptide recognition]]
+
[[Category: Rodionova NA]]
-
[[Category: Ppii helix]]
+
-
[[Category: Proline]]
+
-
[[Category: Rna binding protein]]
+
-
[[Category: Rna splicing]]
+
-
[[Category: Rrm]]
+

Current revision

X-ray Structure of a Core U2AF65/U2AF35 Heterodimer

PDB ID 1jmt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jmt"
Personal tools