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1jmv

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(New page: 200px<br /><applet load="1jmv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jmv, resolution 1.85&Aring;" /> '''Structure of Haemoph...)
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[[Image:1jmv.gif|left|200px]]<br /><applet load="1jmv" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jmv, resolution 1.85&Aring;" />
 
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'''Structure of Haemophylus influenzae Universal Stress Protein At 1.85A Resolution'''<br />
 
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==Overview==
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==Structure of Haemophylus influenzae Universal Stress Protein At 1.85A Resolution==
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BACKGROUND: The universal stress protein UspA is a small cytoplasmic, bacterial protein whose expression is enhanced several-fold when cellular, viability is challenged with heat shock, nutrient starvation, stress, agents which arrest cell growth, or DNA-damaging agents. UspA enhances the, rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. However, neither the structure of UspA nor the biochemical mechanism by which it, protects cells from the broad spectrum of stress agents is known. RESULTS:, The crystal structure of Haemophilus influenzae UspA reveals an asymmetric, dimer with a tertiary alpha/beta fold similar to that of the Methanococcus, jannaschi MJ0577 protein, a protein whose crystal structure revealed a, novel ATP binding motif. UspA differs significantly from the MJ0577, structure in several details, including the triphosphate binding loop of, the ATP binding motif; UspA shows no ATP binding activity. CONCLUSIONS:, Within the universal stress protein family that is delineated by sequence, similarity, UspA is the only member which has been correlated with a, cellular activity, and MJ0577 is the only member which has been assigned a, biochemical activity, i.e., ATP binding. UspA has a similar fold to the, MJ0577 protein but does not bind ATP. This suggests that members of this, protein family will segregate into two groups, based on whether or not, they bind ATP. By implication, one subset of the universal stress proteins, presumably has an ATP-dependent function, while another subset functions, in ATP-independent activities.
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<StructureSection load='1jmv' size='340' side='right'caption='[[1jmv]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jmv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JMV FirstGlance]. <br>
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1JMV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JMV OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jmv OCA], [https://pdbe.org/1jmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jmv RCSB], [https://www.ebi.ac.uk/pdbsum/1jmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jmv ProSAT]</span></td></tr>
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Structure of the universal stress protein of Haemophilus influenzae., Sousa MC, McKay DB, Structure. 2001 Dec;9(12):1135-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11738040 11738040]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/USPA_HAEIN USPA_HAEIN] Required for resistance to DNA-damaging agents (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/1jmv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jmv ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: McKay, D.B.]]
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[[Category: McKay DB]]
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[[Category: Sousa, M.C.]]
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[[Category: Sousa MC]]
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[[Category: SO4]]
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[[Category: universal stress protein]]
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[[Category: uspa]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:23:13 2007''
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Current revision

Structure of Haemophylus influenzae Universal Stress Protein At 1.85A Resolution

PDB ID 1jmv

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