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1jx1

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{{Seed}}
 
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[[Image:1jx1.png|left|200px]]
 
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<!--
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==Chalcone Isomerase--T48A mutant==
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The line below this paragraph, containing "STRUCTURE_1jx1", creates the "Structure Box" on the page.
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<StructureSection load='1jx1' size='340' side='right'caption='[[1jx1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jx1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JX1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DFV:7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE'>DFV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1jx1| PDB=1jx1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx1 OCA], [https://pdbe.org/1jx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jx1 RCSB], [https://www.ebi.ac.uk/pdbsum/1jx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jx1 ProSAT]</span></td></tr>
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</table>
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===Chalcone Isomerase--T48A mutant===
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== Function ==
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[https://www.uniprot.org/uniprot/CFI1_MEDSA CFI1_MEDSA] Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.<ref>PMID:10966651</ref> <ref>PMID:11955065</ref> <ref>PMID:11698411</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11955065}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11955065 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jx1_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11955065}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1JX1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX1 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jx1 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Role of hydrogen bonds in the reaction mechanism of chalcone isomerase., Jez JM, Bowman ME, Noel JP, Biochemistry. 2002 Apr 23;41(16):5168-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11955065 11955065]
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<references/>
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[[Category: Chalcone isomerase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Medicago sativa]]
[[Category: Medicago sativa]]
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[[Category: Single protein]]
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[[Category: Bowman ME]]
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[[Category: Bowman, M E.]]
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[[Category: Jez JM]]
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[[Category: Jez, J M.]]
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[[Category: Noel JP]]
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[[Category: Noel, J P.]]
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[[Category: Open-faced beta sandwich]]
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[[Category: Unique fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:07:03 2008''
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Current revision

Chalcone Isomerase--T48A mutant

PDB ID 1jx1

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