1k0c

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[[Image:1k0c.png|left|200px]]
 
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{{STRUCTURE_1k0c| PDB=1k0c | SCENE= }}
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==Ure2p in complex with S-p-nitrobenzylglutathione==
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<StructureSection load='1k0c' size='340' side='right'caption='[[1k0c]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Ure2p in complex with S-p-nitrobenzylglutathione===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k0c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K0C FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11695904}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=GTB:S-(P-NITROBENZYL)GLUTATHIONE'>GTB</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0c OCA], [https://pdbe.org/1k0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k0c RCSB], [https://www.ebi.ac.uk/pdbsum/1k0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k0c ProSAT]</span></td></tr>
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[[1k0c]] is a 4 chain structure of [[Prion]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0C OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/URE2_YEAST URE2_YEAST] Plays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation. Is also an atypical glutaredoxin without a catalytical cysteine residue. Has glutathione peroxidase and thiol:disulfide oxidoreductase activities in both native and fibrillar form. Also shows insulin disulfide reductase and dehydroascorbic acid reductase (DHAR) actvites.<ref>PMID:1990286</ref> <ref>PMID:8755910</ref> <ref>PMID:10604478</ref> <ref>PMID:10799523</ref> <ref>PMID:15371425</ref> <ref>PMID:19321443</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k0c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k0c ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Prion|Prion]]
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*[[Prion 3D structures|Prion 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011695904</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Belrhali, H.]]
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[[Category: Belrhali H]]
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[[Category: Bousset, L.]]
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[[Category: Bousset L]]
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[[Category: Melki, R.]]
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[[Category: Melki R]]
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[[Category: Morera, S.]]
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[[Category: Morera S]]
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[[Category: Gene regulation]]
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[[Category: Nitrate assimilation]]
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[[Category: Structural genomic]]
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Current revision

Ure2p in complex with S-p-nitrobenzylglutathione

PDB ID 1k0c

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