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1k78

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[[Image:1k78.gif|left|200px]]
 
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==Pax5(1-149)+Ets-1(331-440)+DNA==
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The line below this paragraph, containing "STRUCTURE_1k78", creates the "Structure Box" on the page.
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<StructureSection load='1k78' size='340' side='right'caption='[[1k78]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k78]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K78 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k78 OCA], [https://pdbe.org/1k78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k78 RCSB], [https://www.ebi.ac.uk/pdbsum/1k78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k78 ProSAT]</span></td></tr>
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{{STRUCTURE_1k78| PDB=1k78 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PAX5_HUMAN PAX5_HUMAN] Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.
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== Function ==
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[https://www.uniprot.org/uniprot/PAX5_HUMAN PAX5_HUMAN] May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/1k78_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k78 ConSurf].
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<div style="clear:both"></div>
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'''Pax5(1-149)+Ets-1(331-440)+DNA'''
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==See Also==
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*[[Ets1|Ets1]]
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*[[Paired box protein|Paired box protein]]
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==Overview==
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__TOC__
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Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription.
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</StructureSection>
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==Disease==
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Known disease associated with this structure: Lymphoplasmacytoid lymphoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=167414 167414]]
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==About this Structure==
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1K78 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K78 OCA].
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==Reference==
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Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11779502 11779502]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Garvie CW]]
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[[Category: Garvie, C W.]]
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[[Category: Hagman J]]
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[[Category: Hagman, J.]]
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[[Category: Wolberger C]]
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[[Category: Wolberger, C.]]
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[[Category: Ets domain]]
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[[Category: Paired domain]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:23:33 2008''
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Current revision

Pax5(1-149)+Ets-1(331-440)+DNA

PDB ID 1k78

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