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1k9s

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{{Seed}}
 
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[[Image:1k9s.png|left|200px]]
 
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==PURINE NUCLEOSIDE PHOSPHORYLASE FROM E. COLI IN COMPLEX WITH FORMYCIN A DERIVATIVE AND PHOSPHATE==
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The line below this paragraph, containing "STRUCTURE_1k9s", creates the "Structure Box" on the page.
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<StructureSection load='1k9s' size='340' side='right'caption='[[1k9s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k9s]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K9S FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FM1:2-HYDROXYMETHYL-5-(7-METHYLAMINO-3H-PYRAZOLO[4,3-D]PYRIMIDIN-3-YL)-TETRAHYDRO-FURAN-3,4-DIOL'>FM1</scene>, <scene name='pdbligand=FM2:2-(7-AMINO-6-METHYL-3H-PYRAZOLO[4,3-D]PYRIMIDIN-3-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL'>FM2</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1k9s| PDB=1k9s | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9s OCA], [https://pdbe.org/1k9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k9s RCSB], [https://www.ebi.ac.uk/pdbsum/1k9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k9s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DEOD_ECOLI DEOD_ECOLI] Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules.[HAMAP-Rule:MF_01627]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/1k9s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k9s ConSurf].
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<div style="clear:both"></div>
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===PURINE NUCLEOSIDE PHOSPHORYLASE FROM E. COLI IN COMPLEX WITH FORMYCIN A DERIVATIVE AND PHOSPHATE===
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==See Also==
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*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11786017}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11786017 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11786017}}
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==About this Structure==
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1K9S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9S OCA].
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==Reference==
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Open and closed conformation of the E. coli purine nucleoside phosphorylase active center and implications for the catalytic mechanism., Koellner G, Bzowska A, Wielgus-Kutrowska B, Luic M, Steiner T, Saenger W, Stepinski J, J Mol Biol. 2002 Jan 18;315(3):351-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11786017 11786017]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Purine-nucleoside phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Bzowska A]]
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[[Category: Bzowska, A.]]
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[[Category: Koellner G]]
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[[Category: Koellner, G.]]
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[[Category: Luic M]]
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[[Category: Luic, M.]]
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[[Category: Saenger W]]
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[[Category: Saenger, W.]]
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[[Category: Steiner T]]
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[[Category: Steiner, T.]]
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[[Category: Stepinski J]]
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[[Category: Stepinski, J.]]
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[[Category: Wielgus-Kutrowska B]]
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[[Category: Wielgus-Kutrowska, B.]]
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[[Category: E. coli]]
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[[Category: Glycosyltransferase]]
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[[Category: Purine nucleoside phosphorylase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:00:24 2008''
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Current revision

PURINE NUCLEOSIDE PHOSPHORYLASE FROM E. COLI IN COMPLEX WITH FORMYCIN A DERIVATIVE AND PHOSPHATE

PDB ID 1k9s

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