1k9x

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(New page: 200px<br /><applet load="1k9x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k9x, resolution 2.30&Aring;" /> '''Structure of Pyrococ...)
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[[Image:1k9x.gif|left|200px]]<br /><applet load="1k9x" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1k9x, resolution 2.30&Aring;" />
 
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'''Structure of Pyrococcus furiosus carboxypeptidase Apo-Yb'''<br />
 
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==Overview==
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==Structure of Pyrococcus furiosus carboxypeptidase Apo-Yb==
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The structure of Pyrococcus furiosus carboxypeptidase (PfuCP) has been, determined to 2.2 A resolution using multiwavelength anomalous diffraction, (MAD) methods. PfuCP represents the first structure of the new M32 family, of carboxypeptidases. The overall structure is comprised of a homodimer., Each subunit is mostly helical with its most pronounced feature being a, deep substrate binding groove. The active site lies at the bottom of this, groove and contains an HEXXH motif that coordinates the metal ion required, for catalysis. Surprisingly, the structure is similar to the recently, reported rat neurolysin. Comparison of these structures as well as, sequence analyses with other homologous proteins reveal several conserved, residues. The roles for these conserved residues in the catalytic, mechanism are inferred based on modeling and their location.
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<StructureSection load='1k9x' size='340' side='right'caption='[[1k9x]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k9x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K9X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9x OCA], [https://pdbe.org/1k9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k9x RCSB], [https://www.ebi.ac.uk/pdbsum/1k9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k9x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CBP1_PYRFU CBP1_PYRFU] Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues, but not Pro, Gly, Asp and Glu.<ref>PMID:10595552</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/1k9x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k9x ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1K9X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1K9X OCA].
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*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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Crystal structure of a novel carboxypeptidase from the hyperthermophilic archaeon Pyrococcus furiosus., Arndt JW, Hao B, Ramakrishnan V, Cheng T, Chan SI, Chan MK, Structure. 2002 Feb;10(2):215-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11839307 11839307]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Single protein]]
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[[Category: Arndt JW]]
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[[Category: Arndt, J.W.]]
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[[Category: Chan MK]]
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[[Category: Chan, M.K.]]
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[[Category: Chan SI]]
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[[Category: Chan, S.I.]]
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[[Category: Cheng T]]
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[[Category: Cheng, T.]]
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[[Category: Hao B]]
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[[Category: Hao, B.]]
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[[Category: Ramakrishnan V]]
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[[Category: Ramakrishnan, V.]]
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[[Category: hexxh motif]]
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[[Category: m32 family]]
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[[Category: metallopeptidase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:00:48 2007''
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Current revision

Structure of Pyrococcus furiosus carboxypeptidase Apo-Yb

PDB ID 1k9x

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