2v5z

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[[Image:2v5z.png|left|200px]]
 
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{{STRUCTURE_2v5z| PDB=2v5z | SCENE= }}
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==Structure of human MAO B in complex with the selective inhibitor safinamide==
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<StructureSection load='2v5z' size='340' side='right'caption='[[2v5z]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR SAFINAMIDE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2v5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5Z FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17915852}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SAG:(S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]'>SAG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5z OCA], [https://pdbe.org/2v5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5z RCSB], [https://www.ebi.ac.uk/pdbsum/2v5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5z ProSAT]</span></td></tr>
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[[2v5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5Z OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v5z ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Monoamine oxidase|Monoamine oxidase]]
*[[Monoamine oxidase|Monoamine oxidase]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017915852</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Monoamine oxidase]]
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[[Category: Large Structures]]
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[[Category: Binda, C.]]
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[[Category: Binda C]]
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[[Category: Caccia, C.]]
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[[Category: Caccia C]]
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[[Category: Carotti, A.]]
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[[Category: Carotti A]]
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[[Category: Edmondson, D E.]]
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[[Category: Edmondson DE]]
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[[Category: Mattevi, A.]]
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[[Category: Mattevi A]]
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[[Category: Pisani, L.]]
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[[Category: Pisani L]]
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[[Category: Salvati, P.]]
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[[Category: Salvati P]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Human mao b structure]]
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[[Category: Membrane]]
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[[Category: Mitochondrion]]
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[[Category: Neuroprotection]]
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[[Category: Oxidoreductase]]
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[[Category: Parkinson's disease]]
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[[Category: Reversible inhibitor binding]]
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[[Category: Safinamide]]
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[[Category: Transmembrane]]
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Current revision

Structure of human MAO B in complex with the selective inhibitor safinamide

PDB ID 2v5z

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