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5mgr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human receptor NKR-P1 in glycosylated form, extracellular domain== | |
| - | + | <StructureSection load='5mgr' size='340' side='right'caption='[[5mgr]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5mgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MGR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mgr OCA], [https://pdbe.org/5mgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mgr RCSB], [https://www.ebi.ac.uk/pdbsum/5mgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mgr ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/KLRB1_HUMAN KLRB1_HUMAN] Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.<ref>PMID:16455998</ref> <ref>PMID:16925668</ref> <ref>PMID:8077657</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Stransky | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Blaha J]] | ||
| + | [[Category: Dohnalek J]] | ||
| + | [[Category: Harlos K]] | ||
| + | [[Category: Hasek J]] | ||
| + | [[Category: Koval T]] | ||
| + | [[Category: Skalova T]] | ||
| + | [[Category: Stransky J]] | ||
| + | [[Category: Vanek O]] | ||
| + | [[Category: Yuguang Z]] | ||
Current revision
Human receptor NKR-P1 in glycosylated form, extracellular domain
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Categories: Homo sapiens | Large Structures | Blaha J | Dohnalek J | Harlos K | Hasek J | Koval T | Skalova T | Stransky J | Vanek O | Yuguang Z
