This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5mvm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:48, 7 February 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol==
==X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol==
-
<StructureSection load='5mvm' size='340' side='right' caption='[[5mvm]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+
<StructureSection load='5mvm' size='340' side='right'caption='[[5mvm]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5mvm]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MVM FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5mvm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MVM FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PFL:2,6-BIS(1-METHYLETHYL)PHENOL'>PFL</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvm OCA], [http://pdbe.org/5mvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mvm RCSB], [http://www.ebi.ac.uk/pdbsum/5mvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvm ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PFL:2,6-BIS(1-METHYLETHYL)PHENOL'>PFL</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvm OCA], [https://pdbe.org/5mvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mvm RCSB], [https://www.ebi.ac.uk/pdbsum/5mvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
+
[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
 +
 
 +
==See Also==
 +
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Delarue, M]]
+
[[Category: Gloeobacter violaceus PCC 7421]]
-
[[Category: Fourati, Z]]
+
[[Category: Large Structures]]
-
[[Category: Membrane protein]]
+
[[Category: Delarue M]]
-
[[Category: Transport protein]]
+
[[Category: Fourati Z]]

Current revision

X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol

PDB ID 5mvm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5mvm"
Personal tools