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7aze
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==DNA polymerase sliding clamp from Escherichia coli with peptide 18 bound== | |
| + | <StructureSection load='7aze' size='340' side='right'caption='[[7aze]], [[Resolution|resolution]] 1.82Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7aze]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_2-427-07_S4_C3 Escherichia coli 2-427-07_S4_C3] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AZE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=FCM:(9AS)-8-ACETYL-N-[(2-ETHYL-4-FLUORONAPHTHALEN-1-YL)METHYL]-1,7-DIHYDROXY-3-METHOXY-9A-METHYL-9-OXO-9,9A-DIHYDRODIBENZO[B,D]FURAN-4-CARBOXAMIDE'>FCM</scene>, <scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=SJ8:(~{E})-3-(4-fluorophenyl)prop-2-enoic+acid'>SJ8</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aze OCA], [https://pdbe.org/7aze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aze RCSB], [https://www.ebi.ac.uk/pdbsum/7aze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aze ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA. | ||
| - | + | ==See Also== | |
| - | + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Andre | + | [[Category: Escherichia coli 2-427-07_S4_C3]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Andre C]] |
| - | [[Category: | + | [[Category: Brillet K]] |
| - | [[Category: | + | [[Category: Burnouf DY]] |
| - | [[Category: | + | [[Category: Compain G]] |
| - | [[Category: | + | [[Category: Engilberge S]] |
| - | [[Category: | + | [[Category: Guichard G]] |
| - | [[Category: | + | [[Category: Landolfo M]] |
| - | [[Category: | + | [[Category: Martiel I]] |
| - | [[Category: | + | [[Category: Monsarrat C]] |
| - | [[Category: | + | [[Category: Olieric V]] |
| + | [[Category: Silva da Veiga C]] | ||
| + | [[Category: Wagner J]] | ||
| + | [[Category: Wolff P]] | ||
Current revision
DNA polymerase sliding clamp from Escherichia coli with peptide 18 bound
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