This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7qui
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7qui is ON HOLD Authors: Description: Category: Unreleased Structures) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue== | |
| - | + | <StructureSection load='7qui' size='340' side='right'caption='[[7qui]], [[Resolution|resolution]] 3.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7qui]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.352Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F9I:(2~{S},4~{S},5~{R},6~{R})-5-acetamido-2-[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-acetamido-2-(hydroxymethyl)-4,6-bis(oxidanyl)oxan-3-yl]oxy-3,5-bis(oxidanyl)-6-(sulfooxymethyl)oxan-4-yl]oxy-6-[(1~{R},2~{R})-3-(naphthalen-2-ylsulfonylamino)-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic+acid'>F9I</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qui OCA], [https://pdbe.org/7qui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qui RCSB], [https://www.ebi.ac.uk/pdbsum/7qui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qui ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SIGL8_HUMAN SIGL8_HUMAN] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Atxabal U]] | ||
| + | [[Category: Delgado S]] | ||
| + | [[Category: Ereno-Orbea J]] | ||
| + | [[Category: Franconetti A]] | ||
| + | [[Category: Jimenez-Barbero J]] | ||
| + | [[Category: Lenza MP]] | ||
| + | [[Category: Nycholat C]] | ||
| + | [[Category: Oyenarte I]] | ||
| + | [[Category: Paulson J]] | ||
| + | [[Category: Quintana JI]] | ||
| + | [[Category: Unione L]] | ||
Current revision
Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue
| |||||||||||
