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7qui
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue== | |
| - | + | <StructureSection load='7qui' size='340' side='right'caption='[[7qui]], [[Resolution|resolution]] 3.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7qui]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.352Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F9I:(2~{S},4~{S},5~{R},6~{R})-5-acetamido-2-[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-acetamido-2-(hydroxymethyl)-4,6-bis(oxidanyl)oxan-3-yl]oxy-3,5-bis(oxidanyl)-6-(sulfooxymethyl)oxan-4-yl]oxy-6-[(1~{R},2~{R})-3-(naphthalen-2-ylsulfonylamino)-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic+acid'>F9I</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qui OCA], [https://pdbe.org/7qui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qui RCSB], [https://www.ebi.ac.uk/pdbsum/7qui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qui ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SIGL8_HUMAN SIGL8_HUMAN] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Atxabal U]] | ||
| + | [[Category: Delgado S]] | ||
| + | [[Category: Ereno-Orbea J]] | ||
| + | [[Category: Franconetti A]] | ||
| + | [[Category: Jimenez-Barbero J]] | ||
| + | [[Category: Lenza MP]] | ||
| + | [[Category: Nycholat C]] | ||
| + | [[Category: Oyenarte I]] | ||
| + | [[Category: Paulson J]] | ||
| + | [[Category: Quintana JI]] | ||
| + | [[Category: Unione L]] | ||
Current revision
Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue
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