This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7z3y
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7z3y is ON HOLD Authors: Scaletti, E.R., Stenmark, P. Description: Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand...) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH013545== | |
| - | + | <StructureSection load='7z3y' size='340' side='right'caption='[[7z3y]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7z3y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z3Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=I9U:2-[4-(3,5-dimethylpyrazol-1-yl)-2,6-bis(fluoranyl)phenyl]-~{N}-(4,5,6,7-tetrahydro-1,2-benzoxazol-3-yl)ethanamide'>I9U</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z3y OCA], [https://pdbe.org/7z3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z3y RCSB], [https://www.ebi.ac.uk/pdbsum/7z3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z3y ProSAT]</span></td></tr> |
| - | [[Category: Scaletti | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OGG1_MOUSE OGG1_MOUSE] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Scaletti ER]] | ||
| + | [[Category: Stenmark P]] | ||
Current revision
Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH013545
| |||||||||||
