This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7zly

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:04, 7 February 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7zly is ON HOLD
+
==Crystal structure of human GPCR Niacin receptor (HCA2) expressed from Spodoptera frugiperda==
-
 
+
<StructureSection load='7zly' size='340' side='right'caption='[[7zly]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[7zly]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZLY FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zly OCA], [https://pdbe.org/7zly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zly RCSB], [https://www.ebi.ac.uk/pdbsum/7zly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zly ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/HCAR2_HUMAN HCAR2_HUMAN] Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.<ref>PMID:17932499</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Escherichia coli]]
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: FiBerto JF]]
 +
[[Category: Gao RG]]
 +
[[Category: Han GW]]
 +
[[Category: Kang HJ]]
 +
[[Category: Kenakin T]]
 +
[[Category: Li XM]]
 +
[[Category: Liu ZJ]]
 +
[[Category: Peng W]]
 +
[[Category: Pileski R]]
 +
[[Category: Qu L]]
 +
[[Category: Rao ZH]]
 +
[[Category: Roth BL]]
 +
[[Category: Stevens RC]]
 +
[[Category: Tong JH]]
 +
[[Category: Wang JJ]]
 +
[[Category: Wang Q]]
 +
[[Category: Wu LJ]]
 +
[[Category: Wu YR]]
 +
[[Category: Yang Y]]
 +
[[Category: Zhang XC]]
 +
[[Category: Zhao SW]]

Current revision

Crystal structure of human GPCR Niacin receptor (HCA2) expressed from Spodoptera frugiperda

PDB ID 7zly

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7zly"
Personal tools