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8b2n
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8b2n is ON HOLD Authors: Potempa, J., Ksiazek, M., Goulas, T., Cuppari, A., Rodriguez-Banqueri, A., Arolas, J.L., Lopez-Pelegrin, M., Garcia-Ferrer,...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Potempin A (PotA) from Tannerella forsythia in complex with the catalytic domain of human MMP-12== | |
| + | <StructureSection load='8b2n' size='340' side='right'caption='[[8b2n]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8b2n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Tannerella_forsythia Tannerella forsythia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B2N FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b2n OCA], [https://pdbe.org/8b2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b2n RCSB], [https://www.ebi.ac.uk/pdbsum/8b2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b2n ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | ||
| - | + | ==See Also== | |
| - | + | *[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Tannerella forsythia]] |
| - | [[Category: | + | [[Category: Arolas JL]] |
| - | [[Category: Garcia-Ferrer | + | [[Category: Cuppari A]] |
| - | [[Category: | + | [[Category: Garcia-Ferrer I]] |
| - | [[Category: Ksiazek | + | [[Category: Goulas T]] |
| - | [[Category: | + | [[Category: Guevara T]] |
| - | [[Category: Rodriguez-Banqueri | + | [[Category: Ksiazek M]] |
| + | [[Category: Lopez-Pelegrin M]] | ||
| + | [[Category: Potempa J]] | ||
| + | [[Category: Rodriguez-Banqueri A]] | ||
Current revision
Potempin A (PotA) from Tannerella forsythia in complex with the catalytic domain of human MMP-12
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