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8bcr
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8bcr is ON HOLD Authors: Gauffre, P., Fattorini, V., Canard, B., Ferron, F. Description: DENV3 Methyltransferase in complexed with AT-9010 and SAH ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==DENV3 Methyltransferase in complexed with AT-9010 and SAH== | |
| - | + | <StructureSection load='8bcr' size='340' side='right'caption='[[8bcr]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bcr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BCR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AT9:[[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+phosphono+hydrogen+phosphate'>AT9</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bcr OCA], [https://pdbe.org/8bcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bcr RCSB], [https://www.ebi.ac.uk/pdbsum/8bcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bcr ProSAT]</span></td></tr> |
| - | [[Category: Canard | + | </table> |
| - | [[Category: Fattorini | + | == Function == |
| - | [[Category: Gauffre | + | [https://www.uniprot.org/uniprot/A9LIE0_9FLAV A9LIE0_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dengue virus 3]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Canard B]] | ||
| + | [[Category: Fattorini V]] | ||
| + | [[Category: Ferron F]] | ||
| + | [[Category: Gauffre P]] | ||
Current revision
DENV3 Methyltransferase in complexed with AT-9010 and SAH
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