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8brc

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'''Unreleased structure'''
 
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The entry 8brc is ON HOLD until Paper Publication
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==Crystal structure of the adduct between human serum transferrin and cisplatin==
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<StructureSection load='8brc' size='340' side='right'caption='[[8brc]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8brc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BRC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.17&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH3:AMMONIA'>NH3</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8brc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8brc OCA], [https://pdbe.org/8brc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8brc RCSB], [https://www.ebi.ac.uk/pdbsum/8brc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8brc ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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Authors:
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==See Also==
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*[[Transferrin 3D structures|Transferrin 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ferraro G]]
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[[Category: Galardo F]]
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[[Category: Merlino A]]
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[[Category: Sica F]]
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[[Category: Troisi R]]

Current revision

Crystal structure of the adduct between human serum transferrin and cisplatin

PDB ID 8brc

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OCA

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