8hut
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of MERS main protease in complex with S217622== | |
| - | + | <StructureSection load='8hut' size='340' side='right'caption='[[8hut]], [[Resolution|resolution]] 1.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8hut]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HUT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7YY:6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione'>7YY</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hut OCA], [https://pdbe.org/8hut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hut RCSB], [https://www.ebi.ac.uk/pdbsum/8hut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hut ProSAT]</span></td></tr> |
| - | [[Category: Li | + | </table> |
| - | [[Category: Zhang | + | == Function == |
| + | [https://www.uniprot.org/uniprot/T2B9I2_MERS T2B9I2_MERS] Catalytic subunit of viral RNA capping enzyme which catalyzes the RNA guanylyltransferase reaction for genomic and sub-genomic RNAs. The kinase-like NiRAN domain of NSP12 transfers RNA to the amino terminus of NSP9, forming a covalent RNA-protein intermediate. Subsequently, the NiRAN domain transfers RNA to GDP, forming the core cap structure GpppA-RNA. The NSP14 and NSP16 methyltransferases then add methyl groups to form functional cap structures.[ARBA:ARBA00034461] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Middle East respiratory syndrome-related coronavirus]] | ||
| + | [[Category: Li J]] | ||
| + | [[Category: Lin C]] | ||
| + | [[Category: Zhang J]] | ||
Current revision
Crystal structure of MERS main protease in complex with S217622
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