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398d

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(New page: 200px<br /> <applet load="398d" size="450" color="white" frame="true" align="right" spinBox="true" caption="398d, resolution 1.940&Aring;" /> '''3'-DNA-RNA-5' JUNC...)
Current revision (08:39, 7 February 2024) (edit) (undo)
 
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[[Image:398d.gif|left|200px]]<br />
 
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<applet load="398d" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="398d, resolution 1.940&Aring;" />
 
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'''3'-DNA-RNA-5' JUNCTION FORMED DURING INITIATION OF MINUS-STRAND SYNTHESIS OF HIV REPLICATION'''<br />
 
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==Overview==
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==3'-DNA-RNA-5' JUNCTION FORMED DURING INITIATION OF MINUS-STRAND SYNTHESIS OF HIV REPLICATION==
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During initiation of minus-strand synthesis by HIV-1 reverse, transcriptase, a 3'-DNA-RNA-5' junction is formed involving the 3'-end of, tRNAlys,3. The HIV-RT-associated RNase H cleaves the RNA template strand, specifically, opposite the newly synthesized DNA strand. We have, determined the crystal structure at 1.9 A resolution of an eight-base pair, hybrid duplex representing the junction to identify global or local, structural perturbations which may be recognized by HIV-RT RNase H. The, junction octamer is in a global A-type conformation throughout. A base, pair step with distinct stacking geometry and variable backbone, conformation is located next to the main endonucleolytic cleavage site., This base pair step may serve as a recognition site for HIV-RT RNase H.
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<StructureSection load='398d' size='340' side='right'caption='[[398d]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[398d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=398D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=398D FirstGlance]. <br>
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398D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=398D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=398d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=398d OCA], [https://pdbe.org/398d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=398d RCSB], [https://www.ebi.ac.uk/pdbsum/398d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=398d ProSAT]</span></td></tr>
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==Reference==
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</table>
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Crystal structure of an eight-base pair duplex containing the 3'-DNA-RNA-5' junction formed during initiation of minus-strand synthesis of HIV replication., Mueller U, Maier G, Mochi Onori A, Cellai L, Heumann H, Heinemann U, Biochemistry. 1998 Sep 1;37(35):12005-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9724510 9724510]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Cellai, L.]]
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[[Category: Large Structures]]
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[[Category: Heumann, H.]]
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[[Category: Cellai L]]
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[[Category: Meier, G.]]
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[[Category: Heumann H]]
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[[Category: Mochi-Onori, A.]]
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[[Category: Meier G]]
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[[Category: Mueller, U.]]
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[[Category: Mochi-Onori A]]
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[[Category: a-dna/rna]]
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[[Category: Mueller U]]
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[[Category: double helix]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov 8 14:57:59 2007''
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Current revision

3'-DNA-RNA-5' JUNCTION FORMED DURING INITIATION OF MINUS-STRAND SYNTHESIS OF HIV REPLICATION

PDB ID 398d

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