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3j8w
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==Cryo-EM reconstruction of quasi-HPV16 complex with H263.A2 Fab== | ==Cryo-EM reconstruction of quasi-HPV16 complex with H263.A2 Fab== | ||
| - | < | + | <SX load='3j8w' size='340' side='right' viewer='molstar' caption='[[3j8w]], [[Resolution|resolution]] 13.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3j8w]] is a 13 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3j8w]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J8W FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 13Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j8w OCA], [https://pdbe.org/3j8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j8w RCSB], [https://www.ebi.ac.uk/pdbsum/3j8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j8w ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref> | ||
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| + | ==See Also== | ||
| + | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
[[Category: Human papillomavirus type 16]] | [[Category: Human papillomavirus type 16]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Guan | + | [[Category: Guan J]] |
| - | [[Category: Hafenstein | + | [[Category: Hafenstein S]] |
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Current revision
Cryo-EM reconstruction of quasi-HPV16 complex with H263.A2 Fab
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