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3j8z

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'''Unreleased structure'''
 
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The entry 3j8z is ON HOLD
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==Cryo-EM reconstruction of quasi-HPV16 complex with H16.1A Fab==
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<SX load='3j8z' size='340' side='right' viewer='molstar' caption='[[3j8z]], [[Resolution|resolution]] 14.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3j8z]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J8Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 14&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j8z OCA], [https://pdbe.org/3j8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j8z RCSB], [https://www.ebi.ac.uk/pdbsum/3j8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j8z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref>
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Authors: Guan, J., Hafenstein, S.
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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Description: Cryo-EM reconstruction of quasi-HPV16 complex with H16.1A Fab
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Human papillomavirus type 16]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Guan J]]
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[[Category: Hafenstein S]]

Current revision

Cryo-EM reconstruction of quasi-HPV16 complex with H16.1A Fab

3j8z, resolution 14.00Å

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