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3j9s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Single particle cryo-EM structure of rotavirus VP6 at 2.6 Angstrom resolution== | |
| - | + | <SX load='3j9s' size='340' side='right' viewer='molstar' caption='[[3j9s]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3j9s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_rotavirus_strain_UK/G6 Bovine rotavirus strain UK/G6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J9S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: Grant | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j9s OCA], [https://pdbe.org/3j9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j9s RCSB], [https://www.ebi.ac.uk/pdbsum/3j9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j9s ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VP6_ROTBU VP6_ROTBU] Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices (PubMed:20122940). This capsid constitutes the middle concentric layer of the viral mature particle (PubMed:20122940). The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus (By similarity). Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes (PubMed:20122940). VP6 is required for the transcription activity of the DLP (By similarity).[HAMAP-Rule:MF_04129]<ref>PMID:20122940</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Bovine rotavirus strain UK/G6]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Grant T]] | ||
| + | [[Category: Grigorieff N]] | ||
Current revision
Single particle cryo-EM structure of rotavirus VP6 at 2.6 Angstrom resolution
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