This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3jc2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:43, 7 February 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<SX load='3jc2' size='340' side='right' viewer='molstar' caption='[[3jc2]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<SX load='3jc2' size='340' side='right' viewer='molstar' caption='[[3jc2]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3jc2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JC2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3JC2 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3jc2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JC2 FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">prolactin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jc2 OCA], [https://pdbe.org/3jc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jc2 RCSB], [https://www.ebi.ac.uk/pdbsum/3jc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jc2 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3jc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jc2 OCA], [http://pdbe.org/3jc2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jc2 RCSB], [http://www.ebi.ac.uk/pdbsum/3jc2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jc2 ProSAT]</span></td></tr>
+
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/S61A1_CANLF S61A1_CANLF]
-
Secreted and integral membrane proteins compose up to one-third of the biological proteome. These proteins contain hydrophobic signals that direct their translocation across or insertion into the lipid bilayer by the Sec61 protein-conducting channel. The molecular basis of how hydrophobic signals within a nascent polypeptide trigger channel opening is not understood. Here, we used cryo-electron microscopy to determine the structure of an active Sec61 channel that has been opened by a signal sequence. The signal supplants helix 2 of Sec61alpha, which triggers a rotation that opens the central pore both axially across the membrane and laterally toward the lipid bilayer. Comparisons with structures of Sec61 in other states suggest a pathway for how hydrophobic signals engage the channel to gain access to the lipid bilayer.
+
-
 
+
-
Structure of the Sec61 channel opened by a signal sequence.,Voorhees RM, Hegde RS Science. 2016 Jan 1;351(6268):88-91. doi: 10.1126/science.aad4992. PMID:26721998<ref>PMID:26721998</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 3jc2" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</SX>
</SX>
-
[[Category: Bovin]]
+
[[Category: Bos taurus]]
[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Hegde, R S]]
+
[[Category: Hegde RS]]
-
[[Category: Voorhees, R M]]
+
[[Category: Voorhees RM]]
-
[[Category: Sec61]]
+
-
[[Category: Signal sequence]]
+
-
[[Category: Translocation]]
+
-
[[Category: Transport protein]]
+

Current revision

The structure of the mammalian Sec61 channel opened by a signal sequence

3jc2, resolution 3.60Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3jc2"
Personal tools