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3l0m

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{{Seed}}
 
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[[Image:3l0m.png|left|200px]]
 
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==Crystal structure of Rab1-activation domain and P4M domain of SidM/DrrA from legionella==
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The line below this paragraph, containing "STRUCTURE_3l0m", creates the "Structure Box" on the page.
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<StructureSection load='3l0m' size='340' side='right'caption='[[3l0m]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3l0m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L0M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3l0m| PDB=3l0m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l0m OCA], [https://pdbe.org/3l0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l0m RCSB], [https://www.ebi.ac.uk/pdbsum/3l0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l0m ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Rab1-activation domain and P4M domain of SidM/DrrA from legionella===
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== Function ==
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[https://www.uniprot.org/uniprot/DRRA_LEGPH DRRA_LEGPH] Virulence effector that plays a key role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a GDP-GTP exchange factor (GEF) for the small GTPase Rab1 (RAB1A, RAB1B or RAB1C), thereby converting Rab1 to an active GTP-bound state, leading to the incorporation of Rab1 into LCVs. Also shows RabGDI displacement factor (GDF) activity; however, this probably represents a passive activity following the GEF activity. Also acts as an adenylyltransferase by mediating the addition of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby rendering RAB1B constitutively active. Also has adenylyltransferase activity towards Rab6 and Rab35. Also displays guanylyltransferase activity by mediating the addition of guanosine 5'-monophosphate (GMP) to host RAB1B in vitro; however such activity remains uncertain in vivo. Specifically binds phosphatidylinositol 4-phosphate (PtdIns(4)P) lipids on the cytosolic surface of the phagosomal membrane shortly after infection.<ref>PMID:16824952</ref> <ref>PMID:17947549</ref> <ref>PMID:21822290</ref> <ref>PMID:20064470</ref> <ref>PMID:19942850</ref> <ref>PMID:20176951</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20176951 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_20176951}}
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==About this Structure==
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3L0M is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0M OCA].
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==Reference==
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<ref group="xtra">PMID:20176951</ref><references group="xtra"/>
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[[Category: Legionella pneumophila]]
[[Category: Legionella pneumophila]]
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[[Category: Shao, F.]]
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[[Category: Shao F]]
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[[Category: Zhu, Y.]]
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[[Category: Zhu Y]]
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[[Category: A new novel phosphatidylinositol 4-phosphate-binding domain]]
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[[Category: Gef/gdf of rab1]]
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[[Category: Protein binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 12:35:53 2010''
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Current revision

Crystal structure of Rab1-activation domain and P4M domain of SidM/DrrA from legionella

PDB ID 3l0m

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