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3lle

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[[Image:3lle.jpg|left|200px]]
 
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==X-ray structure of bovine SC0322,Ca(2+)-S100B==
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The line below this paragraph, containing "STRUCTURE_3lle", creates the "Structure Box" on the page.
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<StructureSection load='3lle' size='340' side='right'caption='[[3lle]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LLE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SGE:13-METHYL-13,14-DIHYDRO[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDINE'>SGE</scene></td></tr>
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{{STRUCTURE_3lle| PDB=3lle | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lle OCA], [https://pdbe.org/3lle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lle RCSB], [https://www.ebi.ac.uk/pdbsum/3lle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lle ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
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===X-ray structure of bovine SC0322,Ca(2+)-S100B===
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==See Also==
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21132089 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21132089}}
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==About this Structure==
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[[3lle]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLE OCA].
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==Reference==
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<ref group="xtra">PMID:21132089</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Charpentier, T H.]]
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[[Category: Large Structures]]
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[[Category: Weber, D J.]]
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[[Category: Charpentier TH]]
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[[Category: Wilder, P W.]]
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[[Category: Weber DJ]]
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[[Category: Alpha helical]]
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[[Category: Wilder PW]]
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[[Category: Ef hand]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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Current revision

X-ray structure of bovine SC0322,Ca(2+)-S100B

PDB ID 3lle

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