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3mj9
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==Crystal structure of JAML in complex with the stimulatory antibody HL4E10== | ==Crystal structure of JAML in complex with the stimulatory antibody HL4E10== | ||
| - | <StructureSection load='3mj9' size='340' side='right' caption='[[3mj9]], [[Resolution|resolution]] 2.95Å' scene=''> | + | <StructureSection load='3mj9' size='340' side='right'caption='[[3mj9]], [[Resolution|resolution]] 2.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3mj9]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3mj9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_migratorius Cricetulus migratorius] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MJ9 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mj9 OCA], [https://pdbe.org/3mj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mj9 RCSB], [https://www.ebi.ac.uk/pdbsum/3mj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mj9 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | + | == Function == | |
| - | = | + | [https://www.uniprot.org/uniprot/JAML_MOUSE JAML_MOUSE] Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.<ref>PMID:20813954</ref> |
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==See Also== | ==See Also== | ||
| - | *[[Antibody|Antibody]] | + | *[[Antibody 3D structures|Antibody 3D structures]] |
| - | *[[ | + | *[[3D structures of non-human antibody|3D structures of non-human antibody]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Cricetulus migratorius]] | [[Category: Cricetulus migratorius]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Verdino | + | [[Category: Verdino P]] |
| - | [[Category: Wilson | + | [[Category: Wilson IA]] |
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Current revision
Crystal structure of JAML in complex with the stimulatory antibody HL4E10
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