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3mqe
From Proteopedia
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| - | {{STRUCTURE_3mqe| PDB=3mqe | SCENE= }} | ||
| - | ===Structure of SC-75416 bound at the COX-2 active site=== | ||
| - | {{ABSTRACT_PUBMED_20709553}} | ||
| - | == | + | ==Structure of SC-75416 bound at the COX-2 active site== |
| - | [[3mqe]] is a 4 chain structure with sequence from [ | + | <StructureSection load='3mqe' size='340' side='right'caption='[[3mqe]], [[Resolution|resolution]] 2.80Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3mqe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MQE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=416:(2S)-7-TERT-BUTYL-6-CHLORO-2-(TRIFLUOROMETHYL)-2H-CHROMENE-3-CARBOXYLIC+ACID'>416</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mqe OCA], [https://pdbe.org/3mqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mqe RCSB], [https://www.ebi.ac.uk/pdbsum/3mqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mqe ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Cyclooxygenase|Cyclooxygenase]] | + | *[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Graneto MJ]] | |
| - | [[Category: Graneto | + | [[Category: Kiefer JR]] |
| - | [[Category: Kiefer | + | [[Category: Limburg D]] |
| - | [[Category: Limburg | + | [[Category: Rogier J]] |
| - | [[Category: Rogier | + | [[Category: Springer J]] |
| - | [[Category: Springer | + | [[Category: Wang JL]] |
| - | [[Category: Wang | + | |
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Current revision
Structure of SC-75416 bound at the COX-2 active site
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Categories: Large Structures | Mus musculus | Graneto MJ | Kiefer JR | Limburg D | Rogier J | Springer J | Wang JL
