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5qfy
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5qfy is ON HOLD Authors: Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000396a== | |
| - | + | <StructureSection load='5qfy' size='340' side='right'caption='[[5qfy]], [[Resolution|resolution]] 1.77Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5qfy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QFY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.769Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JO1:1-methyl-N-[(thiophen-2-yl)methyl]-1H-pyrazole-5-carboxamide'>JO1</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qfy OCA], [https://pdbe.org/5qfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qfy RCSB], [https://www.ebi.ac.uk/pdbsum/5qfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qfy ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Brandao-Neto | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Von Delft | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Biel JT]] | ||
| + | [[Category: Brandao-Neto J]] | ||
| + | [[Category: Fraser JS]] | ||
| + | [[Category: Hill ZB]] | ||
| + | [[Category: Kang E]] | ||
| + | [[Category: Keedy DA]] | ||
| + | [[Category: Rettenmaier TJ]] | ||
| + | [[Category: Wells JA]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000396a
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Categories: Homo sapiens | Large Structures | Biel JT | Brandao-Neto J | Fraser JS | Hill ZB | Kang E | Keedy DA | Rettenmaier TJ | Wells JA | Von Delft F
