This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8i9m
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8i9m is ON HOLD Authors: Han, C.W., Kim, H.J. Description: The RAGE and HMGB1 complex Category: Unreleased Structures Category: Han, C.W [[...) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | The | + | ==The RAGE and HMGB1 complex== |
| - | + | <StructureSection load='8i9m' size='340' side='right'caption='[[8i9m]], [[Resolution|resolution]] 5.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8i9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I9M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.19Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i9m OCA], [https://pdbe.org/8i9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i9m RCSB], [https://www.ebi.ac.uk/pdbsum/8i9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i9m ProSAT]</span></td></tr> |
| - | [[Category: Han | + | </table> |
| - | [[Category: Kim | + | == Function == |
| + | [https://www.uniprot.org/uniprot/HMGB1_HUMAN HMGB1_HUMAN] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Han CW]] | ||
| + | [[Category: Kim HJ]] | ||
Current revision
The RAGE and HMGB1 complex
| |||||||||||
